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Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% increase in plasma sildenafil citrate concentrations when co-administered with Sildenafil citrate (50 mg) to good for you volunteers. The guard andefficacy of Viagra with other PDE5 inhibitors, including REVATIO, ingest non beenstudied [see WARNINGS AND PRECAUTIONS]. Physicians should discourse withpatients the expected cardiac risk of intimate bodily function in patients withpreexisting vessel risk of exposure factors. Elongated erecting greater than 4 hours and priapism (dreadful erections greater than 6 hours in duration) get been reportedinfrequently since grocery store blessing of Viagra. In the event of an erecting thatpersists thirster than 4 hours, the patient should essay quick medicalassistance. If priapism is non toughened immediately, penile tissue hurt andpermanent departure of strength could resultant.
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Theseevents, which may be attended by tinnitus and dizziness, get been reportedin temporal association to the intake of PDE5 inhibitors, including Sildenafil. Itis non potential to mold whether these events are related in real time to theuse of PDE5 inhibitors or to former factors [see WARNINGS ANDPRECAUTIONS and ADVERSE REACTIONS]. Physicians should advisepatients of the potential for Viagra to augment the parentage squeeze loweringeffect of alpha-blockers and anti-hypertensive medications.

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