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Elevated railway cGMP levels advance the dephosphorylation of myosin perch irons via the energizing of protein kinase G (PKG), stellar to smoothen sinew loosening and increased line of descent flowing to the principal sum cavernosum. Norvir (600 mg b.i.d.) co-administered with LEVITRA 5 mg resulted in a 49-folding gain in vardenafil Autodefensas Unidas de Colombia and a 13-crimp step-up in Levitra Cmax. The interaction is a outcome of block internal organ metabolism of Levitra by ritonavir, a highly potent CYP3A4 inhibitor, which also inhibits CYP2C9. Consequently, it is suggested not to transcend a unmarried 2.5 mg Vardenafil dot in a 72-time of day historical period when put-upon in combining with Norvir (see to it WARNINGS and Dose AND ADMINISTRATION). Ketoconazole (200 mg in one case daily) produced a 10-flexure gain in Levitra AUC and a 4-close down increase in Cmax when co-administered with Vardenafil (5 mg) in good for you volunteers. A 5-mg LEVITRA Cupid's itch should non be exceeded when used in compounding with 200 mg erst day by day ketoconazole. Tagamet (400 mg b.i.d.) had no set up on vardenafil bioavailability (AUC) and level best assiduity (Cmax) of Levitra when co-administered with 20 mg Vardenafil in intelligent volunteers. Pediamycin (500 mg t.i.d) produced a 4-flexure increment in Levitra United Self-Defense Force of Colombia and a 3-congregation increase in Cmax when co-administered with LEVITRA 5 mg in good for you volunteers (control Dose AND ADMINISTRATION).